Here we show that: both C and S Benin are monophyletic C has accumulated a 4-fold higher recombinational and DNA slippage haplotypic variability than the S Benin allele ( P = 0.003) implying higher antiquity for a long initial lag period, the C alleles did apparently remain very few. To address this apparent paradox, we adopted two partially independent haplotypic approaches in the Mossi population of Burkina Faso where both the local S (S Benin) and the C alleles are common (0.05 and 0.13). HbS, which is lethal in homozygosity, has a multi-foci origin and a widespread geographic distribution in sub-Saharan Africa and Asia whereas HbC, which has no obvious CC segregational load, occurs only in a small area of central West-Africa. Haemoglobin S (HbS β6Glu→Val) and HbC (β6Glu→Lys) strongly protect against clinical Plasmodium falciparum malaria.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |